A two-vehicle crash Wednesday morning closed Highway 121 near Highway 116 in Sonoma, CHP said.

A Toyota Corolla with a driver and two passengers collided with a big rig around 9:30 a.m. sending the sedan into a ditch and ejecting the driver.

Multiple injuries but no fatalities were reported. A REACH medical helicopter was dispatched to the scene. Patients were transported to Queen of the Valley Medical Center in Napa, dispatchers said.

Southbound Highway 121 was closed for at least an hour, and CHP officers controlled traffic on the road.

You can reach Staff Writer Matt Brown at 521-5206 or matt.brown@pressdemocrat.com.