James, however, has had only a bit role on offense and special teams this season. After returning from a knee injury in Week 4, he has seven carries for 31 yards and one kickoff return for 29 yards. He and guard Joe Looney are the only remaining members of what is quickly becoming an infamous 2012 draft class. Both were healthy but did not play in Sunday's 32-20 win over Arizona. Looney has yet to dress after 25 games.
James, a star running back at Oregon and second-round draft pick, showed frustration with his meager role last month.
"Some things I just don't understand at all," he tweeted. "I don't work at State Farm. I'm not trying to be insurance."
James later deleted the entry, but Harbaugh said he was aware of the running back's feelings.
"He'll be back playing," Harbaugh said. "I know the talk about insurance, et cetera. It's no slight to LaMichael. LaMichael is a very good player. And he's a very valued member of our team."