<b>CB Nate Clements vs. WR Roddy White</b>
White destroyed the Niners secondary last year, finishing with a franchise-record 210 yards. One of the enduring images is Clements whiffing on a tackle on White's 90-yard TD catch-and-run.
<b>LT Joe Staley vs. DE John Abraham</b>
The Niners didn't protect Alex Smith well last week and Abraham, who has the second-most sacks in the NFL since 2000 (91.5), could provide more headaches.
<b>S Smith vs. TE Gonzalez</b>
Without Michael Lewis, Smith and rookie Taylor Mays could get some face time with one of the best tight ends in NFL history. White and Mays: 3 career tackles. Gonzalez: 1,011 career catches.