Alex Smith got off to a rough start, and he did not get a lot of help from his teammates. His three first-half interceptions put the 49ers in a hole from which they could not escape.
Frank Gore ended a streak of 23 consecutive games, including playoffs, in which the Eagles did not allow a 100-yard rusher. Gore carried 16 times for 107 yards.
Delanie Walker had a critical first-quarter fumble, and Vernon Davis did not go for a pass from Smith that resulted in an interception. It was not a good day for the wideouts.