CB Chris Culliver ended a Buffalo scoring threat with an interception of Ryan Fitzpatrick's pass to Donald Jones at the San Francisco 2-yard line, with 7 minutes left in the third quarter.

Rookie TE Garrett Celek made his first NFL reception, a 4-yard pass from Smith at the end of the third quarter. WR Mario Manningham got his first score as a 49er after executing a perfect in-out move early in the fourth.

The previous 49ers record for total yardage also came against Buffalo, with 598 in a 34-31 loss on Sept. 13, 1992.

David Akers has now made at least one field goal in all 21 games as a 49er, tying the franchise record for consecutive games set by Bruce Gossett from 1970 to 1972.