LT Joe Staley left the game with a concussion in the third quarter. Alex Boone moved into Staley's spot, with Leonard Davis entering the game at right guard. Harbaugh had no additional information on the injury after the game.
Tarell Brown blocked Lawrence Tynes' field-goal try late in the first half, firing off the left wing to get a finger on the ball. Brown also jumped offside on another Tynes attempt late in the game, giving New York a new set of downs.
With 75 receiving yards on the day, WR Randy Moss (15,032) became just the fourth player in NFL history to surpass 15,000 receiving yards. He joined Jerry Rice (22,895), Terrell Owens (15,934) and Isaac Bruce (15,208). All four played for the 49ers.
Akers' one successful kick allowed him to set a new franchise record with a field goal in 22 consecutive games. Bruce Gossett (21) previously held the mark.
Carlos Rogers played in his 100th NFL game. Unfortunately, he dropped a sure interception and got beat for a touchdown pass by the Giants' Victor Cruz.