"I think they're going to be fine," coach Jim Harbaugh said.
In addition, Harbaugh said the Niners might activate another player from the reserve non-football injury list, with wideout Mario Manningham, cornerback Eric Wright and rookie defensive tackle Tank Carradine closest to being ready.
"It's possible. There's a chance, yeah. I don't like predicting," Harbaugh said.
All three players returned to practice last week. Rookie defensive tackle Quinton Dial came off that list before the game against the Titans.
Manningham made 42 receptions for 449 yards and one touchdown in 12 games and 10 starts last season before injuring his left knee in a loss at Seattle Dec. 23. He underwent reconstructive surgery to repair torn anterior cruciate and posterior cruciate ligaments.