Adding Crabtree to the mix for the 49ers (7-4) would provide a big boost to a receiving corps that made significant strides in a 27-6 win at Washington on Monday night. Crabtree became Colin Kaepernick's top target last year and had career bests of 85 receptions for 1,105 yards and nine touchdowns.
"I'm good," Crabtree said but he wouldn't elaborate. He was activated from the physically unable to perform list Tuesday to the 53-man active roster.
Harbaugh won't tip his hand too early in the week, while also noting that everything depends on how Crabtree gets through practice.
"Good meetings this morning. Good sessions there. Bright-eyed and ready to go," Harbaugh said before the team practiced Wednesday. "Optimistic like I said the other day. Hope for the best and we'll have a plan if he's not able to go. It's pretty much that simple."
Mario Manningham continues to impress playing opposite Anquan Boldin after three games back following knee surgery last year. Manningham hopes his unit can build off a strong performance and develop some consistency.