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WASHINGTON -- Libertarian-minded and moderate Republicans joined forces early Friday with Democrats in the House vote to block the federal government from interfering with states that permit the use of medical marijuana.

The unusual coalition produced a surprising 219-189 vote in the GOP-controlled House that reflects more permissive public attitudes toward medical pot use. It ran counter to the drug's official classification as holding "no currently accepted medical use" and a "high potential for abuse."

Friday's vote came as the House debated a bill funding the Justice Department's budget. Forty-nine Republicans joined all but 17 Democrats who voted in approving a provision to block the Justice Department from interfering with state laws permitting the "use, distribution, possession or cultivation of medical marijuana."

The amendment by conservative GOP Rep. Dana Rohrabacher of California -- the first state to legalize medical marijuana -- came as almost half the states have legalized marijuana for medical uses, such as improving the appetites of cancer patients undergoing chemotherapy. Other states permit the use of a nonpsychoactive marijuana extract to treat epilepsy.

Dale Gieringer, California director for the National Organization for the Reform of Marijuana Laws, or NORML, called the House vote "a warning shot across the bow of the Department of Justice to stay out of it."

Federal interference in California's medical marijuana operations has diminished since last August, when the DOJ announced shifting policy in reaction to legalization of marijuana in Colorado and Washington a year earlier, Gieringer said.

But the potential for federal enforcement actions and raids on the state's dispensaries such as those carried out in earlier times have continued to impede state and local actions to normalize and regulate medical marijuana activity, he said.

The change supported Friday "can only be favorable," he said.

But Gieringer said it would make more sense for Congress to legalize marijuana, at least for medicinal use, than to tell the Justice Department not to enforce existing law.

"That should be the next step," he said.

The measure doesn't address the sale and use of marijuana for recreational purposes in Colorado and Washington, where voters have legalized it over objections from most elected officials. But it comes as the public is taking an increasingly permissive view toward medical pot use, particularly to help people suffering from chronic pain and nausea.

"Public opinion is shifting," said Rohrabacher, R-Huntington Beach, noting a recent Pew Research Center survey that found 61 percent of Republicans support medical marijuana. The numbers are higher for independents and Democrats.

"Despite this overwhelming shift of public opinion, the federal government continues its hard line of oppression against medical marijuana," he said.

Rep. Earl Blumenauer, D-Ore., told opponents that "this train has already left the station."

While almost 4 out of 5 Republicans opposed the amendment, it picked up GOP supporters from libertarians such as Justin Amash, R-Mich., and Thomas Massie, R-Ky., and moderates such as Fred Upton, R-Mich., and Jon Runyan, R-N.J.

Democrats opposed were typically more moderate.

Reps. Mike Thompson, D-St. Helena, and Jared Huffman, D-San Rafael, both voted for the amendment.

Opponents said that marijuana is regulated too loosely by the states and harms the brain. The American Medical Association opposes medical marijuana, calling it a "dangerous drug."

Rep. Andy Harris, R-Md., cited a recent Drug Enforcement Administration study that said that many in the medical marijuana movement are using it as "a means to an end," meaning legalization for recreational use. Harris, a physician, also said that marijuana, unlike other drugs, is typically sold in unrefined form.

Harris said backers of medical marijuana "did not deal with ensuring that the product meets the standards of modern medicine: quality, safety, and efficacy."

"Congress is officially pulling out of the war on medical marijuana patients and providers," said Dan Riffle, director of federal policies for the Marijuana Policy Project.

The measure now heads to the Democratic Senate.

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