Giants rough up Diamondbacks' Zack Greinke, win 4-2

PHOENIX - Johnny Cueto pitched seven strong innings for San Francisco, Zack Greinke had another rough outing at home for Arizona and the Giants opened a four-game series with a 4-2 victory over the Diamondbacks on Thursday night.

Joe Panik hit a two-run homer off Greinke, who fell to 1-3 in five home starts. Chris Owings had an RBI triple for Arizona.

Cueto (5-1) allowed two runs and eight hits, striking out nine and walking two in a matchup of two of the highest-priced free agent pitchers last offseason. Cueto signed a six-year, $130 million contract, which was dwarfed by Greinke’s six-year, $206.5 million deal.

Greinke (3-3) gave up four runs and eight hits in six innings, raising his ERA to 5.26 in eight starts. Greinke led the majors with a 1.66 ERA last season.

Arizona mounted a serious threat in the ninth against closer Santiago Casilla when a pinch-hit double by Phil Gosselin and single by Jean Segura put runners at first and third with one out. Casilla struck out Brandon Drury, but walked Paul Goldschmidt to load the bases. Left-hander Javier Lopez relieved Casilla and got left-handed batting Jake Lamb to ground out, earning his first save since Sept. 19, 2013.

The Diamondbacks fell to 5-13 at home.

Greinke blanked the Giants on one hit through three innings before consecutive singles by Matt Duffy, Buster Posey and Brandon Belt tied it at 1. A fielder’s choice groundout by Hunter Pence gave San Francisco a 2-1 lead.

Denard Span singled to start the fifth. Then, Panik hit Greinke’s first pitch into the right-field seats to make it 4-1.